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71 children and adults (median age 7 years) with chronic obstructive pulmonary disease in which ampicillin-sensitive Haemophilus influenzae were isolated from lower airway secretions were included in a single-blind study comparing amoxycillin/clavulanate and amoxycillin alone. The dosage of...
The in vitro antibacterial activities of 4 quinolones, 4 antipseudomonal beta-lactam antibiotics and tobramycin were determined by an agar dilution technique against 206 clinical isolates of Pseudomonas aeruginosa. 176 isolates derived from blood cultures (BC), the remaining 30 were...
Branhamella catarrhalis was isolated in blood culture from a 6-month-old infant with AIDS. The child had a nasopharyngeal infection with respiratory syncytial virus and pneumonitis with Pneumocystis carinii. Commensal organisms such as B. catarrhalis may be potential pathogens in infants with AIDS.
The ecological effects on the normal intestinal microflora after cefixime tablets in doses of 200 mg twice daily for 7 days were studied in 10 healthy volunteers. Stool specimens were collected before and 2, 4, 7, 14 and 21 days after start of treatment. Plasma samples were collected during 12 h...
Among 600 rotavirus specimens collected in Finland during 1985–1987, 6 isolates were found to be related to serogroup C rotavirus by RNA profile analysis and solid phase immune electron microscopy (SPIEM). The group C isolates originated from 4 children (4.5, 4.5, 6.5 and 7 years old) with...
Staff from a Department of Infectious Diseases ( n =64) were vaccinated against hepatitis B with HBVax® (Merck, Sharp & Dohme), a plasma derived vaccine. Prevaccination testing showed a low prevalence of hepatitis B virus markers (1.4%). Only 1 person showed signs of anamnestic antibody...
A 47-year-old patient with AIDS and cerebral toxoplasmosis was treated with sulfadiazine pyrimethamine for 5 days. After developing a severe rash his regimen was changed to clindamycin 600 mg q 6 h intravenously and pyrimethamine 25 mg daily, given for 37 days. This resulted in improvement of...
Multifocal systemic sporotrichosis (disseminated sporotrichosis) with lobar pulmonary involvement is uncommon. We describe successful treatment with amphotericin B in such a patient and review data from 1 other similar case previously reported and 7 with nonlobar pulmonary involvement.
17 primary health care (PHC) centres participated in a 1-month evaluation of a county urinary tract infection (UTI) management program. A total of 302 patients contributing 355 episodes, dominated by female (93%), lower symptomatic (75%) and Escherichia coli (74%) episodes were studied. In...
In 10 clinical isolates of Escherichia coli the frequency of spontaneous mutation to high levels of resistance to nalidixic acid was >300-fold higher than that to norfloxacin. Norfloxacin resistant mutants could not be detected (mutation frequency: <10 −12 ). However, nalidixic acid resistant...
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