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Objective . The protein tyrosine phosphatase non-receptor type 22 ( PTPN22 ) gene is a member of the PTPs that negatively regulate T-cell activation. A missense single nucleotide polymorphism (SNP) in the PTPN22 gene known as R620W was recently reported to be associated with several autoimmune...
Objective . To determine the extent to which treatment of patients with symptomatic knee osteoarthritis (OA) with non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (ACET) reduces total effusion volume and synovial tissue volume, as quantified by magnetic resonance imaging (MRI)....
Objectives . Herpes zoster (HZ) is a common disorder that causes substantial pain and morbidity. We examined its rate and predictors in rheumatoid arthritis (RA) and non-inflammatory musculoskeletal (MSK) disorders to determine if HZ was increased in RA and whether treatment contributed to the...
Objective . To determine the evidence for the effectiveness of treatments for acute gout and the prevention of recurrent gout. Method . Seven electronic databases were searched for randomized controlled trials of treatments for gout from their inception to the end of 2004. No language...
Objective . To study how soluble citrullinated telopeptides of type I and II collagens inhibit the binding of autoantibodies to the respective antigens immobilized onto solid phase, and to use modifications of previous methods to re-analyse rheumatoid arthritis (RA) and control serum samples....
Background . To compare the core hand and knee examination skills gained by undergraduates taught either by trained patient educators (PEs) or by doctors. Methods . A total of 50 final year medical students were randomized to receive training from PEs or doctors. Group A were taught hand...
Objective . To evaluate the evidence for the effectiveness of acupuncture in peripheral joint osteoarthritis (OA). Methods . Systematic searches were conducted on Medline, Embase, AMED, Cochrane Library, CINAHL, British Nursing Index, PsychINFO and CAMPAIN until July 2005. Hand-searches included...
Objective . Patients with giant-cell arteritis (GCA) usually respond dramatically to corticosteroid treatment. However, recurrences are frequent and corticosteroid requirements are highly variable among patients. The aim of our study was to identify genes potentially involved in disease...
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