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This paper examines some of the problems specifically associated with conducting research into acupuncture and how this can lead to further problems with subsequent systematic reviews. Studies for the treatment of chronic neck pain have been used as examples of how presented information can be...
Objectives . To review the fundamental concepts of pharmacogenetics and analyse how the broad principles of this rapidly emerging field may influence the treatment of rheumatic disease in future. Methods . The names of common rheumatic drugs and the terms ‘pharmacogenetics’,...
Objective . Rheumatoid arthritis (RA) is often complicated by generalized osteopenia due to increased bone resorption by osteoclasts. We analysed a number of cellular and humoral factors that influence osteoclast formation from circulating precursors in RA patients. Methods . Monocytes isolated...
Objective . In synovial fluid (SF) from patients with rheumatoid arthritis (RA), neutrophils are exposed to proinflammatory mediators endowed with either anti‐apoptotic or pro‐apoptotic properties. We investigated neutrophil apoptosis in the presence of SF from 11 RA patients. Methods . SF...
Objective . To determine the clinical significance of serum surfactant protein D (SP‐D) levels in patients with polymyositis/dermatomyositis (PM/DM). Methods . Serum SP‐D levels were assayed using a sensitive enzyme‐linked immunosorbent assay in 59 patients with PM/DM and in 29 healthy...
Objective . To compare the efficacy and safety of intra‐articular injections of two different hyaluronan preparations and placebo in patients with knee osteoarthritis. Methods . In a randomized, patient‐ and observer‐blind, placebo‐controlled and multicentre trial with parallel groups,...
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