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Objective. To describe the spectrum of clinical features in patients with minocycline‐induced lupus (MIL) and determine their response to rechallenge. Methods. The clinical features and laboratory findings of 23 patients with MIL were recorded. Ten patients were rechallenged, and their...
Aim . To investigate the relationship of the instantaneous compressive modulus with its deformation response to cyclic loading typical of that encountered at the knee joint during level walking. Method . The study was performed on 24 osteochondral plugs taken from three unembalmed cadaveric...
Objective . To investigate whether physical trauma may precipitate the onset of rheumatoid arthritis (RA). Method . In a case–control study comparing RA out‐patients with controls attending non‐rheumatology out‐patient clinics, 262 patients and 262 age‐ and sex‐matched controls...
Objective . Glucosyl‐galactosyl pyridinoline (Glc‐Gal‐PYD), which has been identified in urine, is a glycosylated analogue of pyridinoline. The tissue distribution of this molecule has not been yet determined and its utility as a potential biochemical marker of joint degradation in patients...
Objective . To determine whether steroids inhibit the production of inflammatory cytokines by the inhibition of nuclear factor κ B (NF‐ κ B) activation in fibroblast‐like rheumatoid synoviocytes (FLSs) under inflammatory conditions, and to determine whether steroids stimulate the induction...
Objective. This study assessed cellularity in patellar tendinosis with respect to cell proliferation and the expression of platelet‐derived growth factor receptor β (PDGFR β ). Methods. Surgical samples were taken from 11 patients fulfilling criteria of patellar tendinosis and from 12 matched...
Objective. We previously described abnormalities in the bone marrow of patients with rheumatoid arthritis (RA), but were able to shed little light on the pathogenic roles of inflammatory cytokines and proteinases in joint destruction in the subchondral region in RA. This is the first report to...
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