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Background: There are difficulties with the diagnosis of serotonin toxicity, particularly with the use of Sternbach’s criteria. Aim: To improve the criteria for diagnosing clinically significant serotonin toxicity. Design: Retrospective analysis of prospectively collected data Methods: We...
Background: Spondyloepimetaphyseal dysplasia (SEMD) is one of a clinically heterogeneous group of skeletal disorders, characterized by defective growth and modelling of the spine and long bones. Common clinical features include disproportionate short stature, malformed vertebrae and abnormal...
Background: Involuntary weight loss (IWL) is a non-specific symptom frequently found in the setting of a malignant neoplasm. There is no established diagnostic approach for patients presenting with isolated IWL, i.e. without data suggesting a particular organ involvement or system disorder. Aim:...
Background: Wilson’s disease is associated with heavy copper overload, primarily in the liver. Copper is a toxic metal, and might be expected to be associated with cancer induction, as iron is in haemochromatosis. However, liver cancer is currently believed to be extremely rare in this disease,...
Background: Hydrocephalus is a common complication of tuberculous meningitis (TBM). Aim: To study the incidence, associated clinical features, and impact on outcome of hydrocephalus at presentation in TBM. Design: Observational study. Setting: Regional hospital serving 500 000 people. Methods:...
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