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These findings suggest that adolescents are insensitive to cocaine-induced impairment of learning related to amygdala memory system functioning.
Tramadol 200 and 400 mg show evidence of opioid withdrawal suppression without significant observer- and subject-rated opioid agonist effects. The profile of action did not suggest a high risk for tramadol abuse in opioid dependent individuals. Tramadol may be a useful medication for treating...
A modest increase in drug-seeking behavior occurred early within the first extinction session in rats trained to self-administer nicotine in unlimited access sessions. The presence of an extinction burst in nicotine-seeking behavior suggests similar mechanisms underlying extinction of NSA and...
After increasing cocaine’s incentive salience, more early postpartum dams prefer the cocaine-associated chamber than previously reported (Mattson et al. 2001). However, pup-associated chamber preference was still higher in early vs late postpartum. Pup- and cocaine-preferring dams expressed...
Our data suggest that the reduction in dopamine transport can be a possible mechanism related to the maintenance of VCMs in rats. Moreover, diphenyl diselenide seems to be a promising pharmacological agent in the reduction in the prevalence of VCMs in rats.
Both up- and down-regulation of cPLA 2 gene expression are involved in the mechanisms of action of anti-bipolar drugs; astrocytes are a target for these drugs.
NSA, locomotor behavior, and nicotine elimination in rats are decreased during late pregnancy. The present study is the first to characterize NSA during pregnancy in animals, providing a potential model of maternal smoking in humans.
The results suggest that recreational drug use in general, rather than ecstasy use per se, can lead to subtle cognitive impairments and that recent drug use appears to impact strongest on cognitive performance. This study highlights the importance of controlling for the use of all recreational...
These results suggest a role for the dopamine D 3 receptor in the mediation of human PPI, although a contribution from ropinirole’s agonistic activity at the D 2 receptor cannot be entirely excluded. Firm conclusions on the role of the D 3 receptor in the modulation of human PPI can only be...
The dorsal but not ventral striatum plays a critical role in cocaine seeking immediately after abstinence. These data support the theory that chronic cocaine may shift activity from the ventral to dorsal striatum during drug seeking under certain conditions. While not necessary at the time of...
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