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These findings provide the first evidence of the early time course of smoking withdrawal symptoms, although further research is needed to distinguish withdrawal from drug offset effects. Implications for understanding the maintenance of daily smoking and for the treatment of tobacco dependence...
These results suggest that the α1GABA A receptor subtype plays a key role in benzodiazepine-induced increases in consumption of palatable food, whereas the α5GABA A receptor subtype may not be involved in this effect.
Recent evidence suggests differential involvement of opioid receptor subtypes in the anxiolytic efficacy of diverse compounds including conventional benzodiazepines. The insensitivity of 129 mice to the anxiolytic action of chlordiazepoxide, coupled with their atypical anxiolytic response to...
The present data suggest that, as demonstrated for footshock-induced reinstatement of drug seeking, brain CRF, but not corticosterone, plays a critical role in acute food-deprivation-induced reinstatement of heroin seeking.
The results are consistent with complex interactions between genetic (reeler genotype) and epigenetic (prenatal exposure to CPF-O) factors. In the case of some “genetically modulated” parameters (ultrasound vocalization, amphetamine-induced locomotion, and stereotypy), exposure to CPF-O...
Venlafaxine compromises the antiallodynic effects of coadministered gabapentin most probably as consequence-increased diuresis.
The findings from this open-label study suggest that the neurocognitive effects of aripiprazole are at least as good as those of olanzapine.
In unanesthetized rats, chronic lithium administration widely upregulates baseline rCMR glc and potentiates the negative effects on rCMR glc of D 2 -like receptor stimulation. The baseline elevation may relate to lithium’s reported ability to increase auditory and visual evoked responses in...
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