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Alcohol dramatically decreased nocturnal TSH secretion in healthy volunteers.
This study provides neurophysiological evidence that information processing of drug-related information is abnormal in heroin dependent patients. The results provide further evidence for the cognitive and neurobiological accounts of substance dependence such as the incentive-sensitization theory.
Our studies indicate that increased 5HT 2A receptors may be associated with the pathophysiology of bipolar illness and that treatment with lithium further increases the density of 5HT 2A receptors. Whether this increase in 5HT 2A receptors caused by lithium is associated with its therapeutic...
These results demonstrate that acute stress can dampen subjective responses to a low dose of METH, but these effects are short-lived. It remains to be determined what mechanisms mediate this effect.
Both CRF 1 and CRF 2 receptors appear to contribute to the h/r-CRF-induced increases in ASR in mice. These data support the hypothesis that both receptors contribute to the anxiogenic effects of CRF.
Aside from providing a new quantitative approach to studying focused stereotypies, these observation direct attention to the possibility that practice-mediated processes involved in motor skill enhancement may be a part of the neural adaptations that parallel the development of sensitization to...
Olanzapine increases lordosis and midbrain 3α,5α-THP when infused to the VTA which suggest that olanzapine's behavioral effects may result, in part, through actions of 3α,5α-THP, independent of progesterone or corticosterone.
Chronic exposure to street heroin causes a relative increase in concentrations of the active metabolite, M6G. Since the pattern of M6G action seems closer to heroin than to morphine, the increased synthesis of M6G observed in IHU may prolong the narrow window of heroin effects.
These results indicate that METH and AMPH differ in altering working memory and the expression of tolerance, perhaps due to differences in behavioral inhibition.
These results support the notion that there are distinct pathways conveying basal ganglia outflow and demonstrate that the striatopallidal pathway is involved in the generation of the haloperidol-induced tremulous jaw movements. These findings are consistent with some features of current models...
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