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The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent–offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic...
Iloprost, a stable prostacyclin analogue, regulates expression of genes that are involved in inflammation and in cell growth and inhibits the in vitro production of cytokines. We evaluated the effect of an in vivo weekly iloprost treatment on TNF- α and IL6 monocyte production (evaluated by...
Objectives : To determine whether a low fat diet supplemented with ω -3 positively affects quality of life (QOL) in relapsing-remitting MS (RRMS) patients. In this 1-year long double-blind, randomized trial, patients were randomized to two dietary interventions: the “Fish Oil” (FO) group...
Experimental animal and human studies have indicated that long chain polyunsaturated fatty acids (LCPUFA) may enhance calcium absorption, reduce urinary calcium excretion, and increase bone calcium content. In the present study, the effect of LCPUFA, as provided in evening primrose oil, fish and...
The study objective was to determine the effect of feeding food enriched in (n-3) fatty acids (FA) on plasma FA profiles and leukotriene B (LTB) synthesis by stimulated peripheral blood neutrophils from dogs. For 36 weeks, two groups of dogs ( n = 5 ) were fed food that contained either a low...
Milk fat is the major source of energy for breastfed infants; it also supplies polyunsaturated fatty acids (PUFAs) essential for the development of brain, retina, and other organs. Maternal nutritional status is critical for the newborn, and little information exists regarding the PUFA status of...
Both insulin and PPAR- α up-modulate hepatic Δ9, Δ6 and Δ5 desaturating enzymes involved in the biosynthesis of mono- and polyunsaturated fatty acids. Currently, we have examined for 9 days the independent and simultaneous effects of daily glargine insulin and fenofibrate administration on...
The effect of repeated exposure of primary newborn rat brain glial cultures to the endotoxin lipopolysaccharide (LPS), a component of Escherichia coli membrane, on PGE 2 and TNF- α production was examined. PGE 2 production by cell cultures exposed to LPS at a dose of 5 μg/ml, 4 and 24 h after...
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