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The ischaemic vulnerability of the heart of spontaneously hypertensive rats (SHR) is enhanced after feeding an α-linolenic acid (LNA) enriched diet. Because oxygen radical-induced reactions (e.g. lipid peroxidation) are involved in the ischaemic damage, an increased susceptibility of the SHR...
A role of prostaglandins (PGs) and leukotrienes (LTs) in the pathogenesis of nasal polyps has been recently suggested. Cyclooxygenase (CO) products (thromboxane B 2 , PGE 2 and 6-keto PGF 1 alpha) and lipoxygenase (LO) products (LTB 4 and LTC 4 ) were investigated by radioimmunoassay in polyps,...
The purpose of this study was to explore the hypothesis that the dihydropyridine (DHP) binding site of the L-type calcium channel is a high affinity binding site for the cannabimimetic arachidonylethanolamide (AEA). Binding affinities were determined from competition isotherms using the DHP...
Although theophylline has been used in the treatment of asthma for decades, it is not a first line choice any more. It is a well-known bronchodilator, but was recently discovered also to be an anti-inflammatory, immunomodulatory and bronchoprotective agent. Therefore we wanted to establish the...
The localization of the prostaglandin F 2α (FP) receptor was examined in rat tissues by immunohistochemistry and in situ hybridization. Immunohistochemistry on paraffin sections was performed with a rabbit polyclonal antiserum raised against a synthetic peptide derived from the rat FP receptor...
Asphyxiated ( n = 39) and control ( n = 23) were elected for the study. Free radical-mediated lipid peroxidation, prostaglandin E 2 and vitamin E levels were studied and the degree of hypoxic ischaemic encephalopathy was determined in each case. In the hypoxic group the concentration of...
The aim of the present study was to assess the effect of streptozotocin diabetes and insulin treatment on adrenic acid Δ4 desaturation and fatty acid composition of liver microsomes in Wistar rats fed a fat free semi-synthetic basal diet supplemented with 10% EPA-rich marine oil. Results showed...
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