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The kidney is both a source of endothelin (ET) generation and an important target organ of this peptide. The highest concentrations of ET-1 in the body exist in the renal medulla, where it mediates natriuretic and diuretic effects through the ET B receptor subtype. It is proposed that aberrations...
The Ussing model has long provided the conceptual foundation for understanding epithelial transport mechanisms energized by the Na + -K + -ATPase. Plasma membranes may also use the vacuolar (V-type) H + -ATPase as the primary energy source of membrane and epithelial transport. A pure electrogenic...
Recent evidence suggests that pneumonitis induced by many important human viral pathogens may result from exuberant generation of reactive species by inflammatory cells in response to infection. This review summarizes current evidence from animal model studies regarding the beneficial (antiviral)...