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Purpose . This study was undertaken to investigate how fatty acids cause the allosteric binding of drugs to human serum albumin (HSA). The influence of fatty acids on the binding of ketoprofen (KP), an NSAID, to HSA was examined by using a photoaffinity labeling technique. Methods ....
Purpose . The purpose of this study is to examine the ultrasound (US)-enhanced gene expression by the complexes of a plasmid DNA with gelatin derivatives of aminization. Methods . Gelatin derivatives with different introduced extents of ethylenediamine (Ed), spermidine (Sd), and spermine (Sm)...
Purpose . To compare gene expression profiles and drug permeability differences in Caco-2 cell culture and human duodenum. Methods . Gene expression profiles in Caco-2 cells and human duodenum were determined by GeneChip ® analysis. In vivo drug permeability measurements were obtained through...
Purpose . To classify the dissolution and diffusion rate-limited drugs and establish quantitative relationships between absorption and molecular descriptors. Methods . Absorption consists of kinetic transit processes in which dissolution, diffusion, or perfusion processes can become the...
Purpose . The objective of this study was to evaluate the extent and mechanism of uptake of fluorescent chitosan nanoparticles by the A549 cells, a human cell line derived from the respiratory epithelium. Methods . Covalent conjugation with fluorescein-5-isothiocyanate yielded stably labeled...
Purpose . To develop a suitable liposomal carrier to encapsulate neu- roactive compounds that are stable enough to carry them to the brain across the blood-brain barrier with the appropriate surface characteristics for an effective targeting and for an active membrane transport. Methods ....
Purpose: Budesonide and flunisolide anhydrate were crystallized using the solution enhanced dispersion by supercritical fluids (SEDS) technique. The aim was to investigate the possibility of preparing different pure polymorphs. Methods: 0.25% w/v solutions of each drug were prepared from acetone...
Purpose . The purpose of this study was to design novel gastroretentive dosage forms (GRDFs) based on unfolding multilayer polymeric films, to investigate the mechanism of their gastroretentivity in dogs, and to assess the effect of compounding a narrow absorption window drug in a GRDF on the...
Purpose . To investigate the mechanism of action of ternary components within dry powder aerosols. Methods . Ternary interactive mixtures were prepared containing salbutamol sulphate (SS), coarse lactose carriers and either micronized lactose (ML) or micronized glucose (MG). In vitro drug and...
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