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Purpose . To assess the effects of selective lipid extraction and tape stripping on transepidermal water loss (TEWL) at three body regions in the pig. Methods . Lipids were extracted from the abdominal, inguinal, and back regions using three different solvent extraction procedures or cellophane...
Purpose . A genetic neural network (GNN) model was developed to predict the phase behavior of microemulsion (ME), lamellar liquid crystal (LC), and coarse emulsion forming systems (W/O EM and O/W EM) depending on the content of separate components in the system and cosurfactant nature. Method ....
Purpose . To increase the dermal delivery of a lipophilic model compound (LAP), and to deduce the underlying mechanism of enhanced absorption. Methods . Penetration of LAP from mixtures of up to four degrees of saturation into the stratum corneum was evaluated using a tape-stripping method;...
Purpose . To characterize the enantiomers of oxybutynin (OXY) and N-desethyloxybutynin (DEO) following transdermal and oral administration. Methods . OXY was administered either as a single transdermal system over a 96 h wear period or as a single 5 mg immediate-release tablet to 18 healthy male...
Purpose . This work aims to demonstrate a novel chemical assay for rapid screening and analysis of the mode of action of membrane interaction by penetration enhancers. Methods . The new bio-mimetic membrane assembly, consisting of supramolecular aggregates of lipids and conjugated...
Purpose . We previously reported that in patient tumors the expression of the mdr 1 p-glycoprotein (Pgp) resulted in a lower paclitaxel-induced inhibition of DNA precursor incorporation, but a higher apoptosis ( Clin. Cancer Res. 4 :2949-2955, 1998). The present study was to evaluate these...
Purpose . To study at the ultrastructural level which part of the skin is associated with percutaneous iodide transport by passive diffusion and iontophoresis. Methods . Following passive diffusion or iontophoresis of iodide, the morphology and the ion distribution of the skin was preserved by...
Purpose . Evista® (raloxifene HCl) is a nonsteroidal selective estrogen receptor modulator that displays estrogen agonist effects on bone and lipid metabolism but estrogen antagonist effects on the breast and endometrium. The potential for drug-drug interaction between raloxifene and warfarin...
Purpose . This study assessed the influence of mdr1a P-glycoprotein (P-gp) gene disruption, gender and concentration on initial brain uptake clearance ( Cl up ) of morphine, quinidine and verapamil. Methods . Cl up of radiolabeled substrates was determined in P-gp-competent and deficient ( mdr1a...
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