Select All | Select None
Login failed. Please try again.
Forgot your password?
Log in with Facebook
Log in with Google
You can now keep track of new articles from Pharmaceutical Research on your personalized homepage!
Purpose . 31 P CP/MAS NMR is used to characterize stability and changes in solid state properties of disodium clodronate tetrahydrate upon variable temperature and slow dehydration. Methods . Variable temperature 31 P CP/MAS NMR spectroscopy. Results . A fast rise in temperature leads to loss of...
Purpose . Utility values obtained with the standard gamble (SG) method using the probability equivalence approach (PE) have a reported bias due to the "certainty effect." This effect causes individuals to overvalue a positive outcome when it occurs under certainty. Researchers in the decision...
Purpose . Twelve synthetic spider toxin analogs were prepared in an effort to better understand the structure-activity relationships of the polyamine portion of argiotoxin-636 (Arg-636), a noncompetitive NMDA receptor (NMDAR) antagonist. Methods . The l,13-diamino-4,8-diazatridecane portion of...
Purpose . This study aims to assess the drug absorption kinetics of three drugs and compare their resulting first-order intestinal permeation rate constants to their Caco-2 monolayer permeabilities. Methods . In vitro dissolution — in vivo absorption analysis was conducted on four formulations...
Purpose . To apply cocktail approaches for protein binding (PB) and pharmacokinetics (PK) within a discovery program as a means of providing timely systemic exposure (AUC and C max ) data. Methods . For PB data, a procedure of cocktail ultrafiltration, mixed matrix sample preparation and single...
Purpose . Biliary organic anion excretion is mediated by an ATP-dependent primary active transporter, a so-called canalicular multispecific organic anion transporter (cMOAT). As there appear to be many canalicular organic anion transports, we examined the effects of various organic anions and...
Purpose . To investigate the effect of ultrasound on the histological integrity and permeability properties of whole rat skin in vitro . Methods . A defined, field-free source of ultrasound was used to irradiate excised rat skin prior to in vitro transport studies in Franz-type cells using...
results per page
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don't already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don't already have one.
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don't already have one.