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Measuring release rates using compendial systems, especially for sparingly soluble compounds, often produces complex results with less than desired precision and lacks relevance to key formulation or biological parameters. A flow-through approach was used by focusing on convective diffusion and...
The aim of the present study was to formulate non-ionic surfactant vesicles of frusemide to enhance its skin permeation and to develop a transdermal therapeutic system using provesicular approach. The effect of various formulation variables on the transdermal flux, amount of drug deposited in...
This article describes the differences in compaction properties between microcrystalline cellulose (MCC) and α-lactose monohydrate physical mixture, and microcrystalline cellulose co-processed with α-lactose monohydrate (Cellactose®). The different compaction parameters are not only compared...
This study was dedicated to facilitate scale-up in spray drying from an atomization standpoint. The purpose was to investigate differences in operating conditions between a pilot and a production scale nozzle. The intension was to identify the operating ranges in which the two nozzles produced...
The molecules 2-pyridin-3-yl-1H-benzimidazole and 2-pyridin-3-yl-1-(3,4,5-trimethoxybenzoyl)-1H-benzimidazole are compounds that have been synthesized with the aim of finding new inhibitors of the reverse transcriptase enzyme, which is key in the process of cellular contagion of HIV. Because of...
Semisolid matrix capsule formulations of verapamil HCl and diltiazem HCl prepared by hot-melt capsule filling are an especially appealing and simple way to make sustained-release formulations. Semisolid matrices of Gelucire® 50/13 and stearic acid combination eroded and disintegrated at various...
The objective was to measure and compare the specific and general mucin interaction of plasticized and unplasticized pectin films. The pectin types differed in the type and degree of substitution. Mucoadhesive properties were measured by using a texture analyzer. Pectin with an intermediate...
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