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The content of natural antioxidants in extracts of medicinal plants, fruits, and seeds obtained by supercritical fluid extraction was determined by a microcalorimetric technique using the model reaction of induced cumene oxidation. All tested extracts can be divided into two groups according to...
The spermicidal action of a Saussurea salsa (Pall.) Spreng. (SS) extract has been demonstrated by in vivo and in vitro tests in comparison to the reference preparation (Pharmatex). The SS extract in therapeutic concentrations did not produce significant irritating action on mucous membranes and...
A series of mono-and biquaternized derivatives of dipyridylethanes and dipyridylethylenes has been synthesized and characterized with respect to antimicrobial activity. The new compounds exhibit structure-dependent antimicrobial action on both Gram-negative ( E. coli ) and Gram-positive ( St....
The combination of the directed transport of magnet-driven liposomal forms of drugs to a target organ and the local action of the applied magnetic field is a promising direction for the development of new corticosteroid preparations possessing pronounced antiinflammatory activity. The...
The creation of remineralizing liners for the treatment of carious cavities is a currently important task. Data on the standardization with respect to technological, chemical, and microbiological characteristics are presented for a new gel preparation intended for the treatment of deep caries.
The amino acid and elemental composition of birthwort ( Aristolochia clematitis L.) plant species occurring in the Stavropol region has been studied. The analyses showed a high content of tyrosine in the above-ground parts and revealed the presence of 25 elements (K, Ca, P, Mg, Al, Fe, Na, Si,...
Amethod for the synthesis of new structural analogs of the 1–4 somatoliberin peptide sequence is described.
Medicinals not sterilized in the course of their production can be contaminated by microorganisms. The level of microbial contamination of nonsterile medicinal preparations (NSMPs) provides one of the most important criteria for the quality control of pharmaceuticals. Various methods are used in...
The mutagen and DNA damaging properties of a new benzene derivative were studied by means of micronucleus and DNA comet assays in murine lymphoma, and by micronucleus assay in murine bone marrow cells. The compound was not active in vitro and was weakly active in vivo . The new compound is much...
A series of 2-(2-chloro-or 2-bromo-6-difluoromethoxyphenylamino)imidazoline hydrochlorides–clofelin analogs containing difluoromethoxy groups–have been synthesized. The introduction of difluoromethoxy groups decreases the toxicity, increases the duration of hypotensive action, and induces a...
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