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Research highlights ► Peptides derived from α 107–141 were antibacterial whatever the bacterial species. ► The most active peptide is the shortest one: α 137–141. ► Shortest the sequence of the peptide is, lowest the MIC is. ► KYR sequence is the minimal antimicrobial sequence from...
Research highlights ► This study compares the effect of the food modulators ghrelin, NPY and CCK in NOS KO mice. ► Ghrelin did not increase food intake in the homozygous NOS KO mice while wild type controls did experience increased food intake. ► Nitric oxide did show to be a central...
Research highlights ► A novel antimicrobial peptide of 1676 Da was purified from venom of Bellamya bengalensis . ► Sequence of the peptide was determined by tandem mass spectrometry (MS/MS). ► The MIC and MBC values were 8 μg/ml and 16 μg/ml against Staphylococcus epidermidis resistant to...
Research highlights ► First study to consider importance of proline position in buforin II mechanism. ► Sole proline is in ideal position for buforin II membrane translocation. ► Sole proline is in ideal position for bufoirn II antimicrobial activity. ► Results emphasize interplay of...
Research highlights ► Validation of a novel non-invasive method to monitor gastric motility in rodents. ► Chronic overexpression of CRF prevents central vagal activation of gastric contractions in mice. ► Laparotomy and cecal manipulation decrease phasic gastric contractions in both rats...
Research highlights ► In this study we search of new therapeutic alternatives for leishmaniasis. ► We examine antimicrobial synthetic peptides as a molecules with pharmacological potential. ► We use dendritic cells in an in vitro model to study antileishmanial peptides. ► Dermaseptin...
Research highlights ► In this study we purified a new chlorotoxin-like peptide. ► We examined its effect on the U87 glioblastoma cell line. ► We find that this peptide is less active than chlorotoxin. ► The missing of acidic aminoacids is likely responsible for the lower activity. ►...
Research highlights &z.rtrif; The chimeric ITF containing CETP B cell epitope can form the correct trefoil structure. &z.rtrif; The chimeric ITF can resist the proteases digestion in vitro assay. &z.rtrif; The chimeric ITF can induce both of mucosal and systemic immune response in rabbits after...
Research highlights &z.rtrif; Morphine withdrawal induces down-regulation of PPD mRNA and up-regulation of p-CREB. &z.rtrif; Multiple 100 Hz EA shows cumulative effect for suppressing opioid withdrawal syndrome. &z.rtrif; 100 Hz EA normalizes the PPD mRNA level by inhibiting the phosphorylation...
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