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Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. It consists of a nonapeptide component coupled to the ion zinc, which confers biological activity to this molecule. After its discovery in the early 1970, thymulin was characterized as a thymic hormone involved in...
The intracerebroventricular (i.c.v.) infusion of beta-endorphin can cause either a decrease in blood pressure in normal rats or an increase in obese rats. Diet-induced obesity is associated with an increase of hypothalamic mu opioid receptors. Since beta-endorphins act by opioid receptors, we...
Previously, we introduced the RPLKPW sequence, a highly potent hypotensive peptide designed based on ovokinin (2–7), into three homologous sites in the soybean β-conglycinin α′ subunit by site-directed mutagenesis. The modified protein expressed in Escherichia coli reduced blood pressure of...
An antifungal peptide with a molecular mass of 10 kDa was isolated from fruiting bodies of the mushroom Pleurotus eryngii . The peptide, designated as eryngin, inhibited mycelial growth in Fusarium oxysporum and Mycosphaerella arachidicola . It was unadsorbed on DEAE-cellulose and adsorbed on...
The effect of a synthetic peptide (H 92 –G 110 ) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the...
The effects of somatostatin (SRIF) microinjected unilaterally (left or right) at a dose of 10, 50, and 100 ng into the neostriatum of male Wistar rats on exploratory behavior were studied. Unilateral injections of SRIF suppressed dose-related the exploratory activity as decreased the number of...
We investigated the effect of α-melanocyte stimulating hormone (α-MSH) on cerulein induced acute pancreatitis in rats. α-MSH treatment (50 μg per rat, intraperitoneally) prior to cerulein reduced the plasma amylase level, pancreatic weight, pancreatic myeloperoxidase activity and the severity...
Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune...
Helospectin I and II, two closely related mammalian neuropeptides of the secretin/glucagons/vasoactive intestinal peptide (VIP) superfamily of peptides, are co-localized with VIP in nerve fibers surrounding vascular smooth muscle. However, the role if any, VIP receptors play in transducing the...
More information is needed on the physiological role of the tachykinins (TKs), especially neurokinin 3 -receptor (NK 3 ) agonists, in the pancreas. In this paper we investigated and compared the effect of PG-KII (10 −9 to 10 −6 M), a natural NK 3 -receptor agonist, with that of the known...
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