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Immunoglobulin A (IgA) is the most important immunoglobulin of the mucosa. It can protect the mucosal surface from invasion by foreign pathogens. However, only a few studies have mentioned the changes of allergen-specific IgA after immunotherapy in patients with bronchial asthma. In this study,...
The purpose of the present study was to assess the relation between bronchial responsiveness (BR) to exercise and inhaled nonisotonic solutions in children with asthma with exercise-induced broncho-obstruction (EIB). We investigated BR to exercise, inhaled, ultrasonically nebulized 4.5% saline...
We describe two children with biopsy confirmed cellular interstitial pneumonitis (CIP). The first child, a 5.5-year-old girl, presented at 3 years of age with respiratory distress and decreased exercise tolerance. Open-lung biopsy was consistent with CIP. She was initially treated with...
Dean D. Metcalfe, M.D., is Chief, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, in Bethesda, Maryland, and Allergy and Immunology Training Program Director, NIH Clinical Center. He received a Bachelor of Science...
Gastroesophageal reflux is considered one of the etiologies for chronic respiratory and laryngeal symptoms in infants and children, yet the association has been difficult to prove. Dual-channel 24-hour pH probe studies have become more common in the evaluation of these children. To establish...
This multicenter study investigated whether beclomethasone dipropionate in hydrofluoroalkane-134a propellant (HFA-BDP) is effective in controlling asthma in children at a total dose as low as 100 μg/d. A group of 319 children with mild to moderate asthma, ranging in age from 6 to 12 years, were...
Cysteinyl leukotrienes (cysLTs; LTC 4 , LTD 4 , and LTE 4 ) are important mediators in asthma. LTC 4 is metabolized to less active LTE 4 via LTD 4 by glutamyl transpeptidases and dipeptidases. The enzymatic conversion of LTC 4 to LTE 4 may be a regulatory mechanism in asthma. We examined the...
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