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We studied the implication of cytochrome P450 enzymes in the in vitro metabolism of moxidectin (MXD) in homogenates of Haemonchus contortus adult stages (susceptible isolate, Weybridge, UK). After homogenisation in a phosphate buffer, 2 ml of homogenates (equivalent to 1 g of nematodes) were...
Toxoplasma gondii infection results in an infiltration of immune cells. The mechanisms responsible for triggering inflammatory cell infiltration in T. gondii infection are not fully understood. We report that T. gondii -infected HeLa cells induced nuclear factor-kappa B (NF-κB) activation and...
Leucocytozoon caulleryi , the most important pathogen of leucocytozoonsis in several Asian countries, is transmitted by Culicoides arakawae . Although the vector blood meal factors that influence the infectivity of L. caulleryi remain poorly understood, the factors in infected chicken serum...
An enzyme that degraded glycosaminoglycan hyaluronic acid was released during in vitro development of Ascaris suum L3 to L4. The enzyme did not hydrolyze glycosaminoglycan chondroitin sulfate A. One molecular form of hyaluronidase was detected, with a molecular weight estimated at 47.8±8.6 kDa...
An attempt was undertaken to determine whether a concurrent infection of Trichinella spiralis and T. pseudospiralis can reduce cellular infiltrations against the former species during the muscle phase of worm development. BALB/c, nude and CBA/N mice were orally infected with either species or a...
Supplementation of blood with the neolignan burchellin (50 µg/ml), a compound from the arboreous Lauraceae Aniba burchelli , affected the ingestion of blood and the course of excretion of fourth- and fifth-instar larvae of Triatoma infestans , the latter especially within the first 4 h after...
Manzamine A, a sponge-derived alkaloid, was recently shown to possess in vivo antimalarial activity against the blood stages of the rodent malaria parasite Plasmodium berghei . A single intraperitoneal dose of 100 µmol/kg of manzamine A suppressed parasite growth but was followed by parasite...
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