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Our aim was to examine whether an acute fat load could induce changes in the expression of insulin sensitivity-related genes in human peripheral blood mononuclear cells. Selection of candidate genes was based on previous studies with sustained virgin olive oil (VOO) consumption and biological...
A network of molecular interactions between genes and proteins drives animal embryonic development, but much less is known about the role of endogenous low molecular weight metabolites in the early developing embryo. Using liquid chromatography/mass spectrometry (LC-MS), a metabolic...
Pattern recognition techniques suffer from a well-known curse, the dimensionality problem. The microarray data classification problem is a classical complex pattern recognition problem. Selecting relevant genes from microarray data poses a formidable challenge to researchers due to the...
Development of novel vaccines and therapeutics often requires efficient expression of recombinant viral proteins. Here we show that mutations in essential functional regions of conserved influenza proteins NP and NS1, lead to reduced expression of these genes in vitro . According to in silico...
Genome-scale molecular profiling of clinical sample material often results in heterogeneous datasets beyond the capability of standard statistical procedures. Statistical tests for differential expression, in particular, rely upon the assumption that the sample groups being compared are...
Depletion of antioxidants through consumption of a low antioxidant diet has been reported to increase neutrophilic airway inflammation and worsen symptoms of asthma. Using a nutrigenomics approach, this study explores the mechanisms of airway neutrophilic inflammation due to depletion of dietary...
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