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This note reviews “further discussions on choosing the number of animals for an experiment”. Particular emphasis will be given to the table therein.
The radioiodinated (+)- p -iodovesamicol ((+)-pIV), which shows a high binding affinity for sigma-1 (σ-1) receptors, is prepared by an exchange reaction. The specific activity (SA) is fairly low and therefore is insufficient for clinical use. In this study, we prepared (+)-( 125 I)pIV with a...
Introduction In vitro, the dopamine D2 receptor exists in two states, with high and low affinity for agonists. The high-affinity state is the physiologically active state thought to be involved in dopaminergic illnesses such as schizophrenia. The positron emission tomography radiotracer ( 11...
This study reports on the radiosynthesis and feasibility studies of 4′-(methyl- 11 C)thiothymidine ((methyl- 11 C) S -dThd) as a tumor proliferation imaging agent. (Methyl- 11 C) S -dThd was synthesized by rapid methylation of corresponding 5-trimethylstannyl- or 5-tributylstannyl-precursor via...
Small animal positron emission tomography (PET) with 18 F-FDG has been increasingly used for tumor imaging in the murine model. The aim of this study was to establish the anesthesia condition for imaging of lung metastasis tumor using small animal 18 F-FDG PET.
Introduction Noncatabolized thymidine analogs are being developed for use in imaging DNA synthesis. We sought to relate a labeling index measured by immunohistochemical staining bromodeoxyuridine (BUdR) technique to the uptake of 11 C 2′-fluoro-5-methyl-1-β- d -arabinofuranosyluracil (FMAU)...
Melanoma primary tumors can be, in most cases, removed surgically, whereas there is no satisfactory treatment for metastatic melanoma, being almost always lethal at this stage. Therefore, early detection of primary melanoma tumors is essential. The finding that melanocortin-1 receptor (MC1R) is...
Background Overexpression of cyclooxygenase type 2 (COX-2) is triggered by inflammatory stimuli, but it also plays a prominent role in the initiation and progression of various diseases. This study aims to investigate ( 11 C)rofecoxib as a positron emission tomography (PET) tracer for COX-2...
To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson's disease, Alzheimer's disease and depression, we report the synthesis, radiolabeling and in vivo baboon imaging of...
Introduction Our objective was to evaluate the tumor and normal tissue distribution and nuclear importation properties of ( 111 In)-mouse IgG (mIgG) conjugated to tat peptides (GRKKRRQRRRPPQGYG) in athymic mice with subcutaneous BT-474 human breast cancer xenografts.
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