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The specific binding and regional brain pharmacokinetics of new fluorine-18 (( 18 F))-labeled radioligands for the vesicular monoamine transporter (VMAT2) were examined in the rat and primate brain. In the rat, 9-( 18 F)fluoropropyl-(±)-9- O -desmethyldihydrotetrabenazine (( 18 F)FP-(±)-DTBZ)...
Objectives Positron emission tomography (PET) using O -(2-( 18 F)fluoroethyl)- l -tyrosine (FET) has been successfully employed in the diagnostic workup of brain tumors. Knowledge on the mechanisms of the uptake of radiolabeled amino acids into thyroidal tissues and well-differentiated thyroid...
Labeling derivatives of dihydrotetrabenazine (DTBZ) with F-18 ( T 1/2 =110 min) instead of C-11 ( T 1/2 =20 min) would improve their utility and availability for imaging vesicular monoamine transporters (VMAT2) in clinical settings. The successful synthesis, reported previously, of two novel...
Pancreatic cancer has a very poor prognosis with a less than 5% survival rate at 5 years. Neither external beam radiation nor chemotherapy, alone or in combination, have given encouraging results so far. A possible solution might come from the use of targeted therapy such as radioimmunotherapy....
2-( 18 F)fluoro-A-85380 (2-( 18 F)FA) is a new radioligand for noninvasive imaging of α4β2* nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET) in human brain. In most cases, quantification of 2-( 18 F)FA receptor binding involves measurement of free nonmetabolized...
Introduction Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents. Earlier, we reported radiosynthesis of 2′-deoxy-2′-( 18 F)fluoro-1-β- d -arabinofuranosyl-adenine (( 18 F)-FAA) and 3′-deoxy-3′-( 18...
The radioiodinated 3′-fluorothymidine (FLT) analogue 3′-fluoro-5-( 131 I)iodo-2′-deoxyuridine (( 131 I)FLIdU) was synthesized, with iodine mimicking the methyl group of pyrimidine. ( 131 I)FLIdU was accessible by direct electrophilic iodination using Iodogen as oxidant. Optimized amounts of...
Introduction 99m Tc-NC100668 is being developed to aid the diagnosis of thromboemboli. The purpose of this study was to investigate if the presence of excess NC100668 interferes with the biodistribution and blood clot uptake of 99m Tc-NC100668. The secondary aim was to investigate the causes...
The copper(II) complex of ethylglyoxal bis(thiosemicarbazone) (Cu-ETS) was evaluated as a positron emission tomography (PET) radiopharmaceutical for assessment of regional renal perfusion.
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