Select All | Select None
Login failed. Please try again.
Forgot your password?
Log in with Facebook
Log in with Google
You can now keep track of new articles from Nuclear Medicine and Biology on your personalized homepage!
The specific binding and regional brain pharmacokinetics of new fluorine-18 (( 18 F))-labeled radioligands for the vesicular monoamine transporter (VMAT2) were examined in the rat and primate brain. In the rat, 9-( 18 F)fluoropropyl-(±)-9- O -desmethyldihydrotetrabenazine (( 18 F)FP-(±)-DTBZ)...
Objectives Positron emission tomography (PET) using O -(2-( 18 F)fluoroethyl)- l -tyrosine (FET) has been successfully employed in the diagnostic workup of brain tumors. Knowledge on the mechanisms of the uptake of radiolabeled amino acids into thyroidal tissues and well-differentiated thyroid...
Labeling derivatives of dihydrotetrabenazine (DTBZ) with F-18 ( T 1/2 =110 min) instead of C-11 ( T 1/2 =20 min) would improve their utility and availability for imaging vesicular monoamine transporters (VMAT2) in clinical settings. The successful synthesis, reported previously, of two novel...
2-( 18 F)fluoro-A-85380 (2-( 18 F)FA) is a new radioligand for noninvasive imaging of α4β2* nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET) in human brain. In most cases, quantification of 2-( 18 F)FA receptor binding involves measurement of free nonmetabolized...
Pancreatic cancer has a very poor prognosis with a less than 5% survival rate at 5 years. Neither external beam radiation nor chemotherapy, alone or in combination, have given encouraging results so far. A possible solution might come from the use of targeted therapy such as radioimmunotherapy....
Introduction Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents. Earlier, we reported radiosynthesis of 2′-deoxy-2′-( 18 F)fluoro-1-β- d -arabinofuranosyl-adenine (( 18 F)-FAA) and 3′-deoxy-3′-( 18...
The radioiodinated 3′-fluorothymidine (FLT) analogue 3′-fluoro-5-( 131 I)iodo-2′-deoxyuridine (( 131 I)FLIdU) was synthesized, with iodine mimicking the methyl group of pyrimidine. ( 131 I)FLIdU was accessible by direct electrophilic iodination using Iodogen as oxidant. Optimized amounts of...
Introduction 99m Tc-NC100668 is being developed to aid the diagnosis of thromboemboli. The purpose of this study was to investigate if the presence of excess NC100668 interferes with the biodistribution and blood clot uptake of 99m Tc-NC100668. The secondary aim was to investigate the causes...
Introduction Cytosolic thymidine kinase ( TK1 ) catalyzes phosphorylation of thymidine to its monophosphate. TK1 activity is closely related with DNA synthesis, and thymidine analogs derivatized with bulky carboranylalkyl groups at the N-3 position were reported to be good substrates for TK1 ....
results per page
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don't already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don't already have one.
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don't already have one.