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The present study was undertaken to investigate if pretreatment with pharmacological agents could change the organ uptake of 11 C-labelled l -DOPA, and especially if the urinary excretion could be decreased. l -(β- 11 C)DOPA was injected IV into unanesthetized Sprague-Dawley rats. After 20 min...
The accumulation of three 99m Tc(I) alkyl isonitriles was compared in vitro and in vivo using 9L gliosarcoma cells. In vitro , the uptake of 99m Tc-EIBI and 99m Tc-EPI was higher than that of 99m Tc-MIBI. In vivo , however, there was no difference in the tumor concentration at 15 or 60 min...
Vapreotide (RC-160), a somatostatin analog, was labeled with 99m Tc by a direct method and also by using CPTA (1,4,8,11-tetraazacyclotetradecane)as a bifunctional chelating agent. The labeled compounds were evaluated in nude mice bearing experimental human prostate cancers. In these studies, 111...
Although according to the literature S -methyl dithiocarbazate could not form complex directly with 99m TcO 4 − in acidic condition, we deduced that the formation of such complex should be possible based on “cavity model” and the knowledge of coordination chemistry, and that acidic...
6-deoxy-6-iodo- d -glucose (6-DIG) was rapidly taken up by adipocytes. Insulin increased 6-DIG transport in adipocytes isolated from both rats and mice. This stimulation was more important in rat than in mouse adipocytes, in agreement with their respective amount of Glut 4 transporters. In two...
Technetium-99m-labeled alendronate is a new radiopharmaceutical for bone scanning developed under strict quality control at the INNSZ. The purpose of this work was to compare the radiopharmacokinetic data and the dosimetry of 99m Tc-ABP and 99m Tc-MDP in 10 volunteers, after it was tested in...
The potential of both stereoisomers of 11β-methoxy-17α( 123 I)iodovinylestradiol (E- and Z-( 123 I)MIVE) as suitable radioligands for imaging of estrogen receptor(ER)-positive human breast tumours was studied. The 17α-( 123 I)iodovinylestradiol derivatives were prepared stereospecifically by...
Cardiac β-adrenoceptors are assumed to play a key role in chronic heart failure. Although several radioligands labeled with 11 C or 18 F have been synthesized for imaging purposes with positron emission tomography (PET), so far no optimal ligands are available to image cardiac β-adrenoceptors...
The asymmetric synthesis of a series of iodinated β-adrenoceptor ligands is described. One ligand, (S)-(−)-(1-(2-iodophenoxy))-3′-( tert -butylamino)-2′-propanol (CYBL3), is based on the β-adrenoceptor antagonist penbutolol. The other ligands are N -iodovinyl and N -iodoaryl analogues of...
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