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Highlights ► Intranasal siRNA penetrates the olfactory epithelium and lamina propria. ► The olfactory nerve mediates intranasal delivery of siRNA to the olfactory bulb. ► Intranasal siRNA distributes in olfactory nerve, glomerular and mitral cell layers. ► Results support potential...
Highlights ► The IL-10 promoter −819 polymorphism is a risk factor for EOPD. ► The IL-10 promoter −819 polymorphism is a risk factor for female PD. ► No association was found between genotype or allele in IL-10 gene and PD.
Highlights ► In traumatic cortical injury model, we addressed the regional differences of reactive astrocytes. ► We found that the astroglial responses are different depending on the depth from the injury core. ► Various glial progenitors are activated in a regionally segregated manner at...
Highlights ► Latent inhibition occurred in female but not in male. ► Methamphetamine blunted latent inhibition in male rats and enhanced latent inhibition in female rats. ► Sex had an interaction only with methamphetamine and not with apomorphine. ► Postsynaptic DA agonist apomorphine...
Highlights ► 4-Aminopyridine (4-AP) is a potent convulsant. ► We investigated the ictogenic potential of 4-AP in brain slices of pilocarpine treated rats. ► Incidence of seizure like events was reduced in the latent period and in chronic epileptic animals. ► Alterations of potassium...
Highlights ► The effect of thienorphine on NA and DA was examined using an in vivo microdialysis technique. ► Thienorphine had no effect on the level of NA in the LC of dialyzed rats. ► Thienorphine had no effect on the level of DA in the NAc and striatum of dialyzed rats.
Highlights ► Rs4950928 is a single nucleotide polymorphism (SNP) in the CHI3L1 gene. ► G allele of the rs4950928 is a risk allele for schizophrenia. ► G allele of the rs4950928 has higher transcriptional activity of the CHI3L1 gene. ► G allele of the rs4950928 showed higher expression of...
Highlights ► Cocaine is a psychotropic drug with a high potential for abuse. ► Efforts to develop medications for the treatment of cocaine dependence have not been clinically successful. ► SKF 38393 was able to block the preference of cocaine-conditioned place preference. ► The partial...
Highlights ► PC12 cells may be considered as an alternative model to studying MHC I regulation and synaptic plasticity. ► Synapse formation in PC12 cells is affected by MHC I upregulation in response to IFNbeta treatment. ► PC12 cells express CD3-zeta, a subunit of TCR that is fundamental...
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