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Highlights ► Treatment of neurons with 5-HT7 receptor agonist results in an up-regulation of PDGF receptor protein expression. ► PDGF receptors have an increased basal phosphorylation state after 5-HT7 receptor activation. ► 5-HT7 receptor increases PDGF receptor expression in primary...
Highlights ► LTD is facilitated in the daytime but blocked at night. ► LTD is facilitated by sleep deprivation even at night. ► LTD is actually facilitated by high sleep pressure. ► We suggest that LTD is associated with sleep. ► We explain why the induction of LTD is difficult.
Highlights ► α 1 -Adrenoceptor regulates the coordinated responses between SAM and HPA axes. ► α 1 -Adrenoceptor inhibits the hyperfunction of HPA axis induced by CUMS exposure. ► α 1 -Adrenoceptor, not β-adrenoceptor can improve the stress resistance.
Highlights ► Information processing relies on two core stages (N400 and Late Positivity). ► Topicality shapes expectations and internal discourse structuring. ► Referential processing of sentence-initial entity is guided by contextual topic. ► Referential processing of non-initial entity...
Highlights ► Investigated which aspect of an action concept the somatotopic activations reflected. ► Examined the time course of somatotopic activations. ► Revealed early activation of body part representation in action concept comprehension.
Highlights ► Closed-head injury in mice impairs recognition memory up to at least 13 weeks post-insult. ► Closed-head injury in mice does not affect anxiety levels but may provoke mild disinhibition. ► Acute administration of minocycline attenuates the brain injury-induced memory impairment...
Highlights ► Despite similar MSIT performance, MJ users had significantly different activation than controls. ► During the MSIT, MJ smokers had greater activation within cingulate cortex than controls. ► Early onset smokers had more focal activation but made more errors relative to later...
Highlights ► Selective 5-HT receptor agonism of the nucleus accumbens affects appetitive motivation. ► Stimulation of 5-HT 6 receptors increased break point in a progressive ratio task. ► Activation of 5-HT 1/7 receptors inhibited break point at a 4.0 μg/side dose of 5-CT. ► Stimulation...
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