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Highlights ► Fos is transiently expressed (P6) in the MNTB and LSO of control rats. ► Fos expression is sustained through P9 in the MNTB and LSO of kanamycin-treated rats. ► GFAP or TUNEL staining did not parallel with Fos expression in both control and kanamycin-treated rats.
Highlights ► Hypoxia-ischemia is a major cause of perinatal brain injury in the newborn. ► Neotrofin exerts multivariate neuroprotection in several models. ► Neotrofin produced neuroprotective and anti-apoptotic effects in the neonatal hypoxic-ischemic brain.
Highlights ► Intra-CA1 injection of MK-801 induced anxiolytic-like behaviors. ► Intra-CA1 injection of mecamylamine and scopolamine induced anxiolytic-like behaviors. ► Intra-CA1 co-injection of scopolamine increased anxiolytic-like behaviors by MK-801. ► Intra-CA1 co-administration of...
Highlights ► We found small clusters of serotonergic neurons in the dorsal area of caudal raphe. ► Dramatic increase in the number of serotonergic neurons after exposure to thimerosal. ► Embryonic exposure to thimerosal affects early development of serotonergic neurons.
Highlights ► Mesenchymal stem cells (MSCs) become unspread, round shape in simulated microgravity (SMG). ► The differentiated cells from MSCs express higher neuronal markers. ► MSCs secrete more neurotrophins after the stimulation of SMG. ► SMG could enhance the differentiation of MSCs...
Highlights ► Class I antiarrhythmic drugs produced a dose-related spinal anesthetic effect. ► The ranking of potency was bupivacaine > flecainide > quinidine > mexiletine. ► Moreover, flecainide, quinidine and bupivacaine produced similar durations of action. ► These drugs may be...
Highlights ► We used fMRI to examine creation of audio–visual memories of common objects. ► Successful encoding of congruent audio–visual memories activated right LOC. ► Successful encoding of incongruent audio–visual memories activated bilateral STG/STS. ► Creation of both...
Highlights ► Caspase-3 is up-regulated during apoptosis induced by activity deprivation in CGNs. ► Caspase-3 is a target gene of the JNK/c-Jun:ATF2 pathway. ► c-Jun:ATF2 heterodimers bind directly to the ATF site of the caspase-3 promoter in vivo .
Highlights ► Stereological methods. ► Enriched environment increased the total volume of cortex capillaries. ► Enriched environment reduced the mean diameter of the capillaries of females.
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