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Highlights ► Human iPSCs provide an avenue for investigating neurological disease mechanisms. ► Many neurodegenerative diseases are commonly misdiagnosed in live patients. ► Postmortem histopathological review of a donor brain increases diagnostic accuracy. ► Postmortem cells can be made...
Highlights ► We contribute a feature selection process based on the correlation of Fractional Anisotropy (FA) and Mean Diffusivity (MD) voxels with the subject class indicative variable. ► We define and test an image co-registration pipeline for anatomical reference of FA and MD volumes which...
Highlights ► Heroin has been shown to cause spongiform leukoencephalopathy in addicts who had a history of inhaling heated heroin vapor. ► We demonstrate that cerebellar granule cells (CGC) die when maintained in heroin. ► Heroin triggers CGCs die via apoptosis. Heroin-induced apoptosis is...
Highlights ► Histamine excites neurons in the dentate nucleus (DN). ► This excitatory effect by histamine is blocked by histamine H 2 receptor antagonist ranitidine but not by H 1 receptor antagonist triprolidine. ► Histamine H 1 receptor agonist 2-pyridylethylamine dose not elicit any...
Highlights ► The presence and distribution of the receptor RET in the brain of adult zebrafish. ► RET mRNA is expressed in zebrafish brain extracts. ► RET protein is widely diffused in neurons of all major regions of the brain. ► The brain is supposed to be regulated by the ligands that...
Highlights ► Compare cognitive performances in three groups of the Han Chinese population. ► Cognitive deficit is attenuate in three group. ► Executive and semantic function are candidate endophenotypes for schizophrenia.
Highlights ► We evaluated the association between anxiety disorders and Val66Met polymorphism at the BDNF gene in children and adolescents. ► Subjects (cases and controls) were recruited from a community sample. ► Carrying one copy of the Met allele was associated with anxiety disorders in...
Highlights ► Systemically administered galanin influences behavior of Wistar rats. ► Intraperitoneally given galanin increases locomotion/exploration in the open field. ► Galanin alleviates behavioral suppression induced by the restraint stress. ► Galanin modulates the persisting...
Highlights ► Apoptotic processes may alter the neuronal network. ► Annexin-V and TNF-alpha seem to have a role on inflammatory activities during apoptosis. ► A chronic immune activation in schizophrenia has been shown.
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