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The transient receptor potential vanilloid type 1 (TRPV1) is a non-selective ligand-gated cationic channel. The distribution of TRPV1 mRNA in various regions of the brain has been successfully established. Methamphetamine (MAP) is a psychostimulant and a major drug of abuse in many parts of the...
Retinal Müller glial cells are involved in K + ion homeostasis of the tissue. Inwardly rectifying K + (Kir) channels play a decisive role in the process of spatial K + buffering. It has been demonstrated that Kir-mediated currents of Müller cells are downregulated in various cases of retinal...
Recently, a variant in LINGO1 (also denominated as LRRN6A ) rs9652490:A>G gene has been found to associate with increased risk of essential tremor (ET). Because ET and Parkinson's disease (PD) may be ethiologically related, we proceeded to conduct an analysis of the SNP in PD population. In the...
We compared the pre-attentive processing of emotional faces in major depressive disorder (MDD) patients and matched healthy controls as indexed by the visual mismatch negativity (vMMN) elicited by emotional faces presented in upright and inverted orientations. Compared with standard neutral...
Loss of dopaminergic cells induced by α-synuclein accumulation in substantia nigra causes the development of Parkinson's disease (PD). To date, although autophagy has been implicated in the pathology of PD, the molecular mechanism is still unclear. To study the role of autophagy in PD...
Progesterone can enhance cognitive performance among young and aged mice; however, the mechanisms underlying these effects of progesterone are not well-understood. Aged, mice which lack functional progestin receptors (PRKO), or wildtype mice were administered progesterone (10 mg/kg, SC), or...
Precedent of causative multiplication of key gene loci exists in familial forms of both Alzheimer's and Parkinson's diseases. Genetic Creutzfeldt-Jakob disease (CJD) is often clinically indistinguishable from sporadic disease and inexplicably, a negative family history of a similar disorder...
Essential oils are natural, complex and multi-component systems composed mainly of terpenes in addition to some other non-terpenes compounds that are widely used to prevent and treat human diseases. (−)-α-Bisabolol is an unsaturated monocyclic sesquiterpene alcohol found as the major...
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