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The noradrenergic innervation of the frontal cortex and the hypothalamus arises from different brainstem nuclei and neurones projecting to these two brain regions differ topographically and morphologically. In the present study, we investigated whether there is a difference in noradrenaline...
Several lines of evidence suggest that immunisations may be helpful in the prophylaxis and treatment of neurodegenerative amyloidoses like Alzheimer's disease and prion infections. We used a synthetic prion protein-derived peptide (PrP105–125) and a recombinant PrP fragment (PrP90–230) as...
Although our previous study showed the constitutive expression of c-myb in neurons, suggesting that this gene might be involved in the normal function of these cells, there were no reports on the expression pattern of c-myb under pathological conditions. In the present study, we first...
Heterozygous point mutations in the coding region of the human glial fibrillary acidic protein ( GFAP ) gene have been reported in patients with various forms of Alexander disease (AD). We report a case of genetically confirmed adult-onset AD with palatal myoclonus, pyramidal tract signs,...
The 17 amino acid peptide nociceptin has been implicated in pain modulation in the central nervous system. The effects of bath applied nociceptin, and some analogues of nociceptin, upon spontaneous lumbar dorsal root activity have been investigated in an isolated preparation of rat spinal cord....
Affective disorders are more common in women. The forced swim test acts like a depressive stimulus. Hippocampus and frontal cortex 5-HT 1A receptors of female and male Wistar rats subjected to the forced swim test were compared with a sham group. The forced swim test diminishes ( P <0.05) the...
Friedreich ataxia (FRDA) is the most common recessive ataxia caused by reduced expression of frataxin, a nuclear encoded mitochondrial protein. In this study we examined the effects of 3-nitropropionic acid (3-NP) on frataxin expression in FRDA patient and control lymphoblasts and in rat...
Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid β (Aβ) may not be the only pathogenic route to AD. Decreased degradation of Aβ is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme...
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