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The influence of α 2 -autoreceptors on the facilitation of ( 3 H)-noradrenaline release mediated by angiotensin II was studied in prostatic portions of rat vas deferens preincubated with ( 3 H)-noradrenaline. Angiotensin II enhanced tritium overflow evoked by trains of 100 pulses at 8 Hz, an...
A pathological feature of Alzheimer's disease (AD) is an area-specific neuronal loss that may be caused by excitotoxicity-related synaptic dysfunction. Relative expression levels of synaptophysin, dynamin I, complexins I and II, N-cadherin, and αCaMKII were analysed in human brain tissue from AD...
Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder biochemically characterized by the accumulation of the branched-chain α-keto acids (BCKA) α-ketoisocaproic (KIC), α-keto-β-methylvaleric (KMV) and α-ketoisovaleric (KIV) and their respective branched-chain α-amino...
The inflammatory central nervous system response that involves activated microglia and reactive astrocytes may both heal and harm neurons, as inflammatory mediators lead to neuroprotection or excitation at one dose but to injury at a different concentration. To investigate these complex cellular...
The cerebellar cells that account for glutamate-dependent cyclic GMP (cGMP) production, involving activation of the ionotropic glutamate receptors/nitric oxide synthase/soluble guanylyl cyclase pathway, are not fully established. In the present paper we have searched for the localisation of the...
In the present in situ hybridization and immunocytochemical studies in the mouse central nervous system (CNS), a strong expression of spastin mRNA and protein was found in Purkinje cells and dentate nucleus in the cerebellum, in hippocampal principal cells and hilar neurons, in amygdala,...
It has been reported that mutations of γPKC cause hereditary spinocerebellar atrophy type 14 (SCA14). Our recent study has revealed that the SCA14 mutant γPKC is susceptible to aggregation and causes cell death. Among mutations/polymorphisms of γPKC, the R659S mutation was firstly segregated...
The endomorphins (EM1: Tyr-Pro-Trp-Phe-NH 2 , and EM2: Tyr-Pro-Phe-Phe-NH 2 ) are recently discovered endogenous ligands for mu-opioid receptors (MORs) with role of neurotransmitters or neuromodulators in mammals. Cessation of their physiological action may be effected through rapid enzymatic...
Allosteric modulatory effects of 12 biphenyl derivatives of diflunisal and two fenamates were studied on A-type receptors of GABA (GABA A R) via ( 3 H)4′-ethynylbicycloorthobenzoate (EBOB) binding to synaptic membrane preparations of rat forebrain. A simplified ternary allosteric model was used...
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