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Introduction Presbyacusis is the most common cause of auditory dysfunction that is generally associated with aging in industrialized societies.
Genetic variants of the neuronal sortilin - related receptor ( SORL1 ) have been demonstrated to modulate the risk of Alzheimer's disease (AD) in different American and European populations (Rogaeva, E., Meng, Y., Lee, J.H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C.T., Cheng, R.,...
Levels of tumor necrosis factor-α (TNF-α) are increased in the brain in Alzheimer's disease (AD). The TNF-α/TNF-R signaling pathways involve complex interactions between several proteins, including TNF-receptor-associated factor-2 (TRAF-2). We have examined the distribution and levels of...
Cognitive reserve (CR) is the brain's capacity to cope with cerebral damage to minimize clinical manifestations. The ‘passive model’ considers head or brain measures as anatomical substrates of CR, whereas the ‘active model’ emphasizes the use of brain networks effectively. Sixteen...
Abnormal interaction of β-amyloid 42 (Aβ42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Aβ degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix...
Behavioral and event-related potential measures of distraction and reorientation were obtained from children (6 years), young (19–24 years) and elderly adults (62–82 years) in an auditory distraction-paradigm. Participants performed a go/nogo duration discrimination task on a sequence of...
Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases that affect different parts of the central nervous system. However, a review of the literature indicates that certain biochemical reactions involved in neurodegeneration in...
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