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Because the mechanisms of Aβ degradation in normal and Alzheimer's disease brain are poorly understood, we have examined whether various cortical cells are capable of processing this peptide. Rat microglia and astrocytes, as well as the human THP-1 monocyte cell line, degraded A β 1−42 added...
A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18 F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if...
We have recently demonstrated that nicotine administration improves the acquisition and/or memory retention of aged rats in 17-arm radial maze, Lashley III maze, and one-way active avoidance testing. The present study extends our evaluation of nicotine's cognition-enhancing potential by...
Aqueous solutions of β(1–40) peptide spontaneously associate to form pentameric/hexameric complexes that can be demonstrated by SDS-PAGE following treatment with glutaraldehyde and borohydride reduction. Under amyloidogenic conditions of pH and high peptide concentration these aggregates can...
A deficient regulation of neuronal cytosolic calcium levels has been suggested to play a role in the pathogenesis of neurodegeneration. However, evidence for an alteration in cytosolic calcium regulation in old age is at present controversial. The present work was aimed at studying whether...
An age-related increase in stimulation-evoked fractional norepinephrine release has been demonstrated in tail artery of Fischer-344 rats from 6 to 20 months of age. Previous studies have ruled out alterations in function of uptake mechanisms, metabolism, or feedback via prejunctional alpha-2...
Senescent nonhuman primates frequently develop cerebral β-amyloidosis; for reasons that are not yet understood, the primary histological locus of β-amyloid deposition varies in different species. In aged rhesus monkeys ( Macaca mulatta ), fibrillar (congophilic) β-amyloid (Aβ) occurs most...
We examined the neurotoxicity of the 40 amino acid fragment of beta amyloid peptide (Aβ1–40) in cultured hippocampal slices. When injected into area CA3, Aβ1–40 produced widespread neuronal damage. Injection of the reverse sequence peptide, Aβ40-1, or vehicle alone produced little damage....
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