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Background. p38 mitogen‐activated protein kinase (p38 MAPK) followed by the activation of NF‐ κ B participates in the intracellular signal transduction and production of cytokines and chemokines. The pathophysiological roles of p38 MAPK and NF‐ κ B in human glomerulonephritis, however,...
Background. The branchio‐oto‐renal (BOR) syndrome is an autosomal dominant disease characterized by hearing loss of early onset, preauricular pits, branchial clefts, and early progressive chronic renal failure in up to 40% of family affected members. So far, it has not received due attention...
Background. Chronic kidney disease is characterized by increased synthesis and inhibited destruction of collagenous and non‐collagenous matrix proteins. Elevation of collagen fragments has been demonstrated in the serum and urine of patients with renal disease, but the dynamics of renal matrix...
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