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Background. Patients with end‐stage renal disease have an increased risk of developing coronary artery disease (CAD). The cardiovascular mortality of dialysis patients is 10–15 times higher compared with the general population. The aim of our study was to evaluate the morphological...
Background. The objectives of the present trial were to compare the efficacy and safety of two i.v. iron preparations with respect to haemoglobin levels, iron status and recombinant human erythropoetin (rHuEpo) dosage requirements in stable, rHuEpo‐treated haemodialysis patients (maintenance...
Background. Vasopeptidase inhibition (VPI) represents a new therapeutic principle including both inhibition of angiotensin‐converting enzyme (ACE) and neutral endopeptidase (NEP). The present study investigated the effect of the vasopeptidase inhibitor omapatrilat on endothelin‐1...
Background. The proliferation of glomerular epithelial cells (GEC) is usually observed in crescentic glomerulonephritis. However, the regulation of GEC proliferation is not fully understood. Although it is known that interleukin‐1 β (IL‐1 β ) has a mitogenic effect on mesangial cells and is...
Background. Chronic renal failure (CRF) is associated with an increased risk of ischaemic heart disease (IHD), but the mechanisms responsible are controversial. We investigated the relationship of two sets of candidate mechanisms—indices of LDL oxidation and markers of inflammatory...
Background. During haemodialysis the blood‐membrane contact causes a release of platelet granule content, which contains platelet‐derived growth factor AB (PDGF‐AB). In view of the potential role of this in altering biocompatibility during haemodialysis, we evaluated the intra‐ and...
Background. The new cyclosporin (CsA) formulation, Neoral ® , has different pharmacokinetics compared with Sandimmune ® (SIM). Larger area under the curve (AUC) values with equivalent trough blood values are reached when Neoral is administered at equivalent doses to SIM. Previously, we showed a...
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