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Double-stranded DNA viruses package their genomes into procapsids via an ATP-driven nanomotor. This ingenious motor configuration has inspired the development of biomimetics in nanotechnology. Bacteriophage ϕ29 DNA-packaging motor has been a popular tool in nanomedicine. To provide information...
Frequency domain fluorescence lifetime imaging microscopy (FLIM) has been used in combination with laser scanning confocal microscopy to study the cellular uptake behavior of the antitumor drug doxorubicin (DOX) and micellar-encapsulated DOX (PLyAd-DOX). The endocytosis uptake process of...
Fibrillar amyloid is the hallmark feature of many protein aggregation diseases, such as Alzheimer's and Parkinson's diseases. A monoclonal single-chain variable fragment (scFv) targeting insulin fibrils was isolated using phage display technology and an atomic force microscopy (AFM) mica...
Polyelectrolyte complexes (PECs) assembled from oppositely charged polymers were endowed with gadolinium (Gd) and evaluated to determine cytotoxicity and magnetic resonance image (MRI) contrast enhancement in vivo. Chitosan grafted with Gd diethylenetriaminepentaacetic acid (DTPA) was...
We proposed for the first time a surgical term, the nanocryosurgery, for efficient tumor treatment through combining the theories of cyrosurgery and nanotechnology. Simulations were performed on the combined phase change bioheat transfer problems in a single cell level and its surrounding...
Superparamagnetic nanoparticles have been synthesized that could potentially be used to magnetically target therapeutics within the body. The magnetic targeting and successful in-flow capture of 330-nm and 580-nm agglomerates of these magnetite nanoparticles was performed using a 0.5-T magnet....
Quercetin, an effective flavonol used as an antioxidant, was investigated for its anxiolytic and cognitive activities in male Wistar rats. Oral quercetin (300 mg/kg body weight/day) was compared with oral and intranasal quercetin liposomes (20 μg/day). Quercetin liposomes, in a mixture of egg...
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