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Studies from our laboratory have demonstrated several advantages of conducting the Syrian hamster embryo (SHE) cell transformation assay at pH 6.70 compared to that done historically at higher pH values (7.10–7.35). These include reduction of the influence of SHE cell isolates and fetal bovine...
Cell transformation models have been established for studying the cellular and molecular basis of the neoplastic process. Transformation models have also been utilized extensively for studying mechanisms of chemical carcinogenesis and, to a lesser degree, screening chemicals for their...
A series of publications of the results of National Toxicology Program (NTP) studies (Tennant et al. (1987) Science, 236, 933–941; Haseman et al. (1990) J. Am. Stat. Assoc., 85, 964–971; Shelby et al. (1993) Environ. Mol. Mutagen., 21, 160–179) show that the commonly used short-term...
A comprehensive review of the Syrian Hamster Embryo (SHE) cell transformation literature was performed in order to catalogue the chemical/physical entities which have been evaluated for in vitro cell transformation potential. Both reduced pH (pH 6.7) and standard pH (pH 7.1–7.3) SHE cell...
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