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The conventional w / w + eye assay in Drosophila has been used for the last 10 years for genotoxic evaluation of a broad number of chemicals with different mechanisms of action. Although chemicals that induce genotoxic effects by mechanisms other than covalent binding to DNA are difficult to...
3‐Nitrobenzanthrone (3‐NBA) is one of the most potent mutagens in the Ames Salmonella typhimurium assay and a suspected human carcinogen recently identified in diesel exhaust and in airborne particulate matter. 3‐Aminobenzanthrone (3‐ABA), 3‐acetylaminobenzanthrone (3‐Ac‐ABA) and N...
The activation of telomerase in phytohemagglutinin‐stimulated peripheral lymphocytes is thought to play a role in telomere maintenance and DNA repair. Considering the importance of this enzyme in both cancer and senescence, we studied the effects of the telomerase inhibitor...
The single cell gel electrophoresis (SCGE) assay, also known as the Comet assay, is one of the most promising genotoxicity tests developed in recent years to measure and analyse DNA damage in single cells. The present study was undertaken to assess the in vivo genotoxicity of the synthetic...
We have shown previously that UVC irradiation of benzo( a )pyrene diol epoxide (BPDE)‐adducted DNA (BPDE/UVC) induces an increase in mutation frequency in the supF gene greater than the calculated additive value derived from either treatment alone, with a greater absolute increase in the level...
A yeast ( Saccharomyces cerevisiae ) DNA repair reporter assay termed the GreenScreen ® assay (GSA) is described. This is a novel, cost‐effective genotoxicity screen, developed to provide a pre‐regulatory screening assay for use by the pharmaceutical industry and in other applications where...
Benzene is a human leukemogen and the metabolites are thought to be deeply involved in benzene leukemogenesis. In a previous study we reported the molecular analysis of p ‐benzoquinone ( p‐ BQ) mutagenesis by using a supF shuttle vector plasmid and here we report the mutagenesis of the other...
Arsenic is classified as a carcinogen for humans, but as a possible genotoxic agent. Thus, taking into account the controversial data about how arsenic compounds are able to induce genetic damage, we investigated the possible genotoxic activity of different arsenic compounds in the TK6 human...
Inorganic arsenic is a known human carcinogen, yet its mechanism of action remains poorly understood. Epidemiological data suggest that arsenic exposure interacts with UV radiation exposure to increase the risk of skin cancer. Studies have suggested that arsenic is able to impair DNA repair...
Mutagenicity of drinking water is due not only to industrial, agricultural and urban pollution but also to chlorine disinfection by‐products. Furthermore, residual disinfection is used to provide a partial safeguard against low level contamination and bacterial re‐growth within the...
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