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Abstract We studied the mechanisms and sites of activator actions of 2-2-(3,4-dichloro-phenyl)-2,3-dihydro-1 H -isoindol-5-ylamino-nicotinic acid PD307243 (PD) and 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea NS1643 (NS) on the human ether-a-go-go -related gene (hERG) channel expressed in...
Abstract α4 and β2 nicotinic cholinergic receptor (nAChR) subunits can assemble in heterologous expression systems as pentameric receptors with different subunit stoichiometries that exhibit differential sensitivity to activation by acetylcholine, yielding biphasic concentration-effect curves....
Abstract The neurotrophic peptide PACAP (pituitary adenylate cyclase-activating polypeptide) elevates cAMP in PC12 cells. Forskolin and dibutyryl cAMP mimic PACAP's neuritogenic and cell morphological effects, suggesting that they are driven by cAMP. Comparison of microarray expression profiles...
Abstract Arylamine N -acetyltransferase 1 (NAT1) is a phase II xenobiotic-metabolizing enzyme that plays an important role in the biotransformation of aromatic drugs and carcinogens. NAT1 activity has long been associated with susceptibility to various cancers. Evidence for a role of NAT1 in...
Abstract There are a considerable number of reports identifying and characterizing genetic variants within the CYP2C9 coding region. Much less is known about polymorphic promoter sequences that also might contribute to interindividual differences in CYP2C9 expression. To address this problem,...
Abstract Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels mediating fast cholinergic synaptic transmission in the brain and at neuromuscular junctions. We used the structure of the acetylcholine binding protein from Lymnaea stagnalis to model the chicken α7...
Abstract T-type calcium channels are important for a variety of physiological processes such as brain and heart function. Proper regulation of these channels by second messengers is fundamental; however, our knowledge of the molecular pathways that regulate T-type calcium channels is limited in...
Abstract Although the toxic effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) on T cells in vivo have been well characterized, attempts to reproduce these findings in vitro have not been successful. In the current study, we examined whether activation or the presence of dendritic cells...
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