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Abstract Although both nitric oxide (NO) and glutamate within the rostral ventrolateral medulla (RVLM) are important mediators of the central cardiovascular regulation, little is known about the functional interactions between these two mediators. Herein, we investigated the possible role of NO...
Abstract Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous substrates for hsEH. Enzyme activity in humans shows high interindividual variation (e.g., 500-fold in liver)...
Abstract Opioids mediate their analgesic effects by activating μ-opioid receptors (MOR) not only within the central nervous system but also on peripheral sensory neurons. The peripheral analgesic effects of opioids are best described under inflammatory conditions (e.g., arthritis). The present...
Abstract The nuclear receptor peroxisome proliferator-activated receptor (PPAR) is activated by a diverse group of acidic ligands, including many peroxisome proliferator chemicals present in the environment. Janus tyrosine kinase-signal transducer and activator of transcription (JAK-STAT)...
Abstract Knowing the importance for research and pharmacological uses of proper ligand classification into agonists, inverse agonists, and antagonists, the aim of this work was to study the behavior of tiotidine, a controversial histamine H2 receptor ligand. We found that tiotidine, described...
Abstract CYP2C19 is an important human drug-metabolizing enzyme that metabolizes a number of clinically used drugs including the antiulcer drug omeprazole, the anxiolytic drug diazepam, the β-blocker propranolol, the antimalarial drug proguanil, certain antidepressants and barbiturates, and the...
Abstract Voltage-dependent L-type Ca 2+ channels are modulated by the binding of Ca 2+ channel antagonists and agonists to the pore-forming α 1c subunit (Ca V 1.2). We recently identified Ser 1115 in IIIS5-S6 linker of α 1C subunit as a critical determinant of the action of 1,4-dihydropyridine...
Abstract Oltipraz, a promising cancer chemopreventive agent, has been recognized as a monofunctional inducer selectively activating phase II carcinogen-detoxifying enzymes via the antioxidant responsive element (ARE). However, we report here that oltipraz also induces rat glutathione S...
Abstract The recently introduced camptothecin-derived chemotherapeutic agents have demonstrated remarkable promise in cancer therapy and as such have been approved for use in humans for the treatment of ovarian, lung, and colon cancer. CPT-11 is a prodrug that is activated by esterases to yield...
Abstract Isoprostanes are liberated when reactive oxygen species (ROS) mediate the peroxidation of arachidonic acid or other polyunsaturated fatty acids. Because exposure to ROS is associated with tissue damage in the lung, we examined whether exposure to isoprostanes elicited a response in...
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