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Abstract Targeted drug delivery to endothelial cells lining the vascular lumen will provide effective, precise andsafe therapeutic interventions for treatment of diverse disease conditions. Rational design of such drug delivery systems (DDS) includes the following intertwined tasks: 1) selection...
Abstract The histamine H 3 receptor is an attractive G protein–coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a role in cognitive and homeostatic functions. Drug discovery efforts by numerous pharmaceutical companies have focused on the...
Abstract Prostaglandins (PG) are synthesized by the sequential action of phosholipases, cyclooxygenases (COX)-1 and COX-2, and specific terminal synthases, and exert their diverse biological effects through several membrane receptors. In particular, PGE2 is involved in many normal and...
Abstract The accumulation of amyloid-β peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-β peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the...
Abstract Iron is essential for many biological processes however excess concentrations can be harmful to many tissues. Its amounts must therefore be carefully regulated in all cells of the body including those in the brain. Increased amounts of iron have been reported in many neurodegenerative...
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