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Abstract The production of safe pharmaceuticals at affordable costs is one of the great challenges of our times. Research has proven that transgenic plants can fulfill this need. This review focuses on the peculiar features of plant cells that allow high accumulation of recombinant proteins. The...
Abstract Among the salutary effects of aspirin (acetylsalicylic acid, ASA) are its ability to keep platelets from aggregating and blood from clotting too readily, to reduce fever, and to ameliorate inflammation. Aspirin also is beneficial in preventing colorectal cancer; however, aspirin is not...
Abstract Among tyrosine kinases, the Janus kinases (Jaks) are the only ones known to possess two kinase domains: a C-terminal functional kinase domain and a nonfunctional pseudokinase domain located just N-terminal to the functioning domain. The pseudokinase domain, or Jak homology domain 2...
Abstract The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors that control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination...
Abstract The retinal pigment epithelium (RPE) is a monolayer of cells that appear phenotypically regular, but which exhibit striking cell-cell variability in content of melanin and lipofuscin granules, and in expression of many proteins. This naturally occurring cell heterogeneity likely arises...
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