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Abstract B lymphocytes and T lymphocytes utilize several proteins with common functions to transduce signals from their respective receptors. However, at the hierarchial signalling level of SLP-76 Src homology 2(SH2) domain-containing leukocyte protein of 76-kDa and LAT (linker for activation of...
Abstract A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2 . The presence of the gene was discovered when Tph 1 –/– mice were found to express normal amounts of serotonin in brain, but not in the periphery. Additionally, Tph1 –/– mice showed no...
Abstract The development of new drugs for the brain has not kept pace with progress in the molecular neurosciences, because the majority of new drugs discovered do not cross the blood-brain barrier (BBB). Although approximately 100% of large-molecule drugs do not cross the BBB, the problem is...
Abstract Claire M. Fraser speaks with ease, humor, and pride about the people and projects that have contributed to the success of The Institute for Genomic Research (TIGR) in Rockville, Maryland. She’s certainly had plenty of practice, having given multiple stories and interviews to local and...
Abstract Foxglove and its constituents therapeutic agent digitalis have been used for centuries for the treatment of heart failure. All digitalis-like cardiotonic steroids enhance heart contraction through a mechanism involving the inhibition of the Na + ,K + – ATPase. Recentlt, Rathore and...
Abstract Vasomotion, rhythmic oscillations in vascular tone caused by local changes in smooth muscle constriction and dilation, has been observed since the invention of the microscope, but its physiological role and its underlying mechanism remain elusive. Present in many tissues, vasomotion...
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