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Previous analyses of the T-cell receptor (TCR) repertoire utilized in response to the 1–102 fragment of the λ cI repressor protein and specific for the immunodominant amino acid 12–26 region in the context of I-E k , have shown this repertoire to be extremely restricted. In contrast, here we...
Grasspollen,especially of rye-grass (Lolium perenne), represents an important cause of type I allergy. Identification of IgE-binding (allergenic) epitopes of major grass pollen allergens is essential for understanding the molecular basis of interaction between allergens and human IgE antibodies...
The Fc receptor (FcR) γ subunit was originally discovered as a homodimeric subunit of the high-affinity IgE receptor (FcεRI). But it was recently found to be a common signal-generating subunit of Fc receptors including IgG Fc receptors (FcγRs) and IgA Fc receptor (FcαR), and furthermore to...
T cell responses are highly specific and T cell receptors (TCRs) can recognise subtle differences in major histocompatibility complex (MHC)-peptide complexes. While nominal peptide antigens usually act as full agonists that trigger the whole spectrum of T cell responses, some peptides exhibiting...
Many T cell responses are dominated by restricted TCR expression and can range from repeated usage of particular TCR Vβ- and\or Vα-elements, to the preferential usage of both V- and J-elements, often in conjunction with conserved V-D-J or V-J junctional sequences. Cytotoxic T lymphocytes...
To investigate the role of Fas in experimental autoimmune encephalomyelitis (EAE) in mice, we examined the susceptibility of EAE in C57BL\6 (B6). lpr mice lacking Fas. The frequency of myelin oligodendrocyte glycoprotein (MOG)-induced EAE in B6. lpr mice was significantly lower than that in B6...
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