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The innate capacity of mice to conrrol mycobacterial multiplication early after infection is controlled by the resistant allele of the Nramp-1 Bcg gene. The Bcg gene seems to be involved in a pathway leading to macrophage activation. It differentially affects the ability of BCG-resistant...
IgM antibodies can be secreted in at least two functional polymeric forms that can be distinguished according to subunit composition. While IgM hexamers comprise six H 2 L 2 monomeric subunits, pentamers contain an additional polypeptide, the J chain. In the presence of high abundance J chain...
CD4 engagement triggers an early signaling cascade which initiates late events such as transcription factor activation. The outcome of CD4 engagement is T-cell commitment to alternative, dramatically different fates, such as activation and apoptosis. We have tested a panel of anti-CD4 mAbs...
We have analysed the rearrangement status of the immunoglobulin heavy (IgH) chain locus during progression of a T-cell lymphoblastic lymphoma displaying multiple IgH rearrangements as demonstrated by variable heavy (V h ) gene family specific polymerase chain reaction (PCR) analysis. The tumor...
Transcription of the gene elements that form the variable region of immunoglobulin heavy chains has been proposed to represent the process that controls access for the recombination enzymes in their sequential steps of catalysis. Evidence for germline transcription of V H gene elements, as part...
The effects of mutagenesis of residues of a major T cell epitope were investigated in order to expand knowledge from synthetic peptides to the naturally processed antigen. The impact of substitutions within the core of the immunodominant p61-80 PT19 mycobacterial epitope was ascertained in...
Complement receptor type one (CR1) in primates has several remarkable structural features including a size polymorphism ( M r 190000, 220000, 250000 and 280000) in man, multiple size variants ( M r 55000–220000) among non-human primates, and a partial amino-terminal duplication (CR1-like gene)...
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