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A synthetic DNA construct has been developed as a standard molecule whereby murine cytokine mRNA molecules can be quantified by the reverse transcription-polymerase chain reaction (RT-PCR). The construct, designated Cytoquant 1, allows the quantification of murine IL-1α, IL-2, IL-3, IL-4, IL-5,...
Apoptosis can be induced in the human leukemic T-cell line Jurkat when these cells are stimulated by several known T-cell activators. Among the stimuli that activate Jurkat cells, calcium ionophore A23187, phytohemagglutinin and cross-linked monoclonal antibody anti-CD3 are the best inducers of...
Monoclonal antibodies (mAbs) specific to (4-hydroxy-3-nitrophenyl)acetyl (NP) were prepared at various times after immunization and the amino acid sequences of VH and Vλ1 in these mAbs were deduced from cDNA nucleotide sequences. Replacements due to somatic mutation were not found in day 7 mAbs...
Previous studies in our laboratory demonstrated that murine cerebral microvessel smooth muscle cells (SMC) activate syngeneic CD4 + T-cells in vitro . These T-cells, or their culture supernatants, in turn, strongly inhibit proliferation of the SMC. The present study focuses on IFN-γ as a...
A uniquely developed series of totally § § The term “totally” is used to distinguish these antibodies from humanized immunoglobulins or monoclonals produced from mouse/human heterohybridomas. human monoclonal antibodies (mAbs) were examined for their complement fixing properties in...
Several cell surface receptors involved in cellular activation by antigen, such as the B-cell and T-cell antigen receptors, and receptors for IgE and IgG (FcϵRI and FcγRIII) show substantial similarities in structure and signaling pathways. An essential step in the activation of immune cells...
The structure of the N -linked sugar chains attached to three IgG antibodies, identical in amino acid sequence except for the changes required to introduce the carbohydrate addition sites, has been determined. All three antibodies are specific for dextran but differ in their ability to bind...
In this work, we propose a model for the structure of the antigen-antibody complex formed by human H-ferritin and an antibody that specifically recognizes it. We cloned and sequenced the antibody gene, predicted the antibody three-dimensional structure, and reconstructed the H-ferritin-antibody...
The invariant chain (Ii) region that interacts with class II and inhibits premature peptide binding has been mapped to amino acids 82–107, known as CLIP. It is unclear whether CLIP binds directly to the class II peptide binding groove and thus competitively blocks binding of other peptides, or...
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