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The AZFc region of the human Y chromosome is frequently deleted in men with spermatogenic failure and contains many multicopy genes. The best‐characterized gene family within this region is the Deleted in AZoospermia ( DAZ ) gene family, which is present in four nearly identical copies. Recent...
The role of matrix metalloproteinases (MMP), especially newly described MMP, in trophoblast invasion during human embryo implantation is poorly understood. In this report, using a model of early pregnancy in the rhesus monkey, we have examined the expression and localization of the most recently...
The objective of this study was to quantify the relative expression of inhibin α, inhibin/activin β A , β B , β C , follistatin, activin receptors and β‐glycan genes in placental tissue of term pre‐eclamptic patients and controls to investigate if these genes are up‐regulated in the...
Isolating fetal erythroblasts from first trimester maternal blood offers a promising non‐invasive alternative for prenatal diagnosis. The aim of this study was to characterize the biological properties of first trimester primitive erythroblasts to facilitate their enrichment from first...
Human labour is associated with persistently increased nuclear factor kappa B (NF‐kB) activity in amnion. In this study we have shown that this involves only the p65 and p50 NF‐kB subunits and is associated with an increase in the expression of p65 ( P < 0.05), and of the NF‐kB binding...
The purpose of the study was to examine the occurrence of programmed cell death (apoptosis) in normal and chromosomally aneuploid testis and ovaries during the second trimester of human development. Such information may be useful in understanding normal and abnormal germ cell development and...
Cryptorchidism is the commonest malady to affect newborn male infants. Until recently, the molecular aetiology of this syndrome was unclear. Cryptorchidism may be part of a broader testicular dysgenesis syndrome, wherein a disturbance in steroid hormone metabolism, possibly through a perturbed...
Chemokines are implicated in the implantation process. The aim of this study was to investigate mRNA expression and protein levels of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in human endometrium throughout the menstrual cycle, during HRT and in the human blastocyst. The regulation of...
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