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During development, dorsal root ganglia (DRG) neurons differentiate in various subpopulations, nociceptive neurons belonging in the small-diameter class. This study addresses the role played by DRG11, a transcription factor expressed in the spinal area of projection of small-diameter DRG neurons,...
Nestin-positive cells were targeted for pRb, p107 and p130 (pRb f ) inactivation by expression of T 121 , a truncated SV40 large T antigen that selectively binds to and inactivates pRb f . Cre expression was initiated under GFAP control, resulting in T 121 expression restricted to neuroprogenitor...