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NeuroD/BETA2 (referred to as NeuroD hereafter) is a basic helix–loop–helix (bHLH) transcription factor that is required for the development and survival of a subset of neurons and pancreatic endocrine cells in mice. Gain-of-function analyses demonstrated that NeuroD can (i) convert epidermal...
To reveal the spectrum of genes that are modulated in Charcot–Marie–Tooth neuropathy type 1A (CMT1A), which is due to overexpression of the gene coding for the peripheral myelin protein 22 ( pmp22 ), we performed a cDNA microarray experiment with cDNA from sciatic nerves of a rat model of the...
Neuronal progenitor cells (NPCs) residing in the adult subependymal zone (SEZ) are a potential source of expandable cells for autologous transplantation to replace neurons lost in multiple types of brain injury. To characterize the capacity of these cells for neuronal differentiation in a mature...
The voltage-gated sodium channel Na v 1.8 produces a tetrodotoxin-resistant current and plays a key role in nociception. Annexin II/p11 binds to Na v 1.8 and facilitates insertion of the channel within the cell membrane. However, the mechanisms responsible for removal of specific channels from...
Voltage-gated sodium channels cluster at sites of action potential generation and propagation by interacting with partner proteins such as neurofascin, an adhesion molecule in the L1 family, and ankyrin-G, a spectrin-binding protein required for sodium channel accumulation at axon initial...
The development of the nervous system (NS) requires the coordinated migration of multiple waves of neurons and subsequent processes of neurite maturation, both involving selective guidance mechanisms. In Caenorhabditis elegans , unc-53 codes for a new multidomain protein involved in the...
Recently, receptor protein tyrosine phosphatase-σ (RPTPσ) has been shown to inhibit axon regeneration in injured peripheral nerves. Unlike the peripheral nervous system (PNS), central nervous system (CNS) neurons fail to regenerate their axons after injury or in disease. In order to assess the...
The autosomal recessive neuromuscular disorder associated with the enervated ( enr ) mouse transgene insertion manifests impaired peripheral nerve regeneration due to defects in Schwann cells and resembles the myodystrophy ( Large myd ) phenotype. Here we show that the enr transgene has...
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