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Highlights ► Five TAC and six TACR genes were identified in teleost. ► The teleostean evolutionary history of TAC and TACR genes was clarified. ► Full length of zebrafish TAC3s and TACR3s were cloned. ► The ligand-receptor interactions between NKB peptides and TACR3s were examined.
Highlights ► MC5R internalizes independently of β-arrestins and recycles to cell surface. ► α-MSH binding to MC5R promotes a biphasic ERK activation, an early and a late phase. ► The early peak of pERK is G i -driven; the sustained is β-arrestins dependent. ► A small fraction of...
Highlights ► ER and PR are enriched in different subsets of normal human breast epithelial cells. ► PR transcripts are enriched in the bipotent progenitor subfraction. ► A rare subset of steroid receptor-positive cells co-express common basal markers. ► Estrogen regulation of PR is cell...
Highlights ► Epidermal growth factor stimulates expression of all activin subunits in the zebrafish ovary. ► EGF regulates activin subunits via diverse signaling pathways in the follicle cells. ► EGF stimulation of inhbaa and inhbb involves MAPK, p38 MAPK, PKC and PKA pathways. ► EGF...
Highlights ► Sparus aurata Myostatin-2 promoter contains putative cis regulatory elements including E-boxes. ► High transcriptional activity in myoblasts, myotubes, and differentiated neural cells. ► The promoter directs GFP expression in myofibers of zebrafish embryos. ► High...
Highlights ► We stimulated the calcium sensing receptor (CaSR) in adipose cells and tissue with the calcimimetic cinacalcet. ► Cinacalcet elicited an elevation in the expression of inflammatory cytokines. ► NFκB inhibition partly reverted the observation suggesting it mediates the effect...
Highlights ► Palmitate programmed embryonic stem cells towards white fat. ► The effects were partially mimicked by 2-bromopalmitate and by the GPR120 analogue GW9508. ► Palmitate had a preferential effect on the differentiation of subcutaneous fat. ► Palmitate stimulated expression of...
Highlights ► Bisphosphonates and statins increase OPG expression. ► Bisphosphonates and statins inhibit the expression of CD9, M-CSF, and RANKL. ► Bisphosphonates and statins suppressed Ras signallings and activated p38MAPK. ► Future studies on the clinical application of this new finding...
Highlights ► The role of melatonin in the regulation of autophagy and mitophagy. ► The molecular mechanisms by which melatonin influences apoptosis. ► The function of melatonin in reducing cellular loss in specific disease states.
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